![]() Next generation sequencing of RNA (RNA-Seq) has greatly accelerated the discovery of novel fusion genes in cancer. Fusion genes including BCR-ABL, PML-RAR and EML4-ALK have become targets for therapy in cancer, and as a result there is great interest in defining the full complement of oncogenic fusion genes. Chromosomal rearrangements have the potential to alter gene function in many different ways for example, they may produce chimeric fusion proteins that gain new functionality, or place a gene under the control of alternative regulatory elements.
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